Release from the Spanish Observatory of Medicinal Cannabis

Spanish Observatory of Medicinal Cannabis
Spanish Observatory of Medicinal Cannabis

On the occasion of the sad news published yesterday in France, in which cannabis was falsely indicated as cause of one death and five severe cases among the patients of a clinical trial, the Spanish Observatory of Medicinal Cannabis states:

  1. The French Ministry Health of France has officially confirmed  that the drug used in this trial does not contain any cannabinoid, neither natural nor synthetic. Therefore, users of medicinal cannabis can be completely confident.
  2. The wrong mention of cannabis in the news published has generated a situation of alarm completely unnecessary and unfair.  For this reason, we stress the need for truthful, accurate and scientific information on cannabis and its therapeutic purposes.
  3. Bial laboratories (responsible for the drug used in this trial) informed that this drug is an inhibitor compound of the FAAH protein (fatty acid amide hydrolase).
  4. Other inhibitor compounds of the FAAH protein have already been used in clinic trials without toxicity. Although we still don't have the necessary data to explain the adverse symtoms observed in the French trial, these could be caused either by toxicity problems inherent in the molecular characteristics of the drug or because the inhibitor action of the FAAH protein. In this latter case, FAAH inhibition may cause an increase in fatty acid amides in the body. Since we have tens - even hundreds - of fatty acid amides in our body, it is extremely difficult to define, at this very moment, which compound could be responsible for these serious adverse effects.

Cordially,

Spanish Observatory of Medicinal Cannabis

Members of the Spanish Observatory of Medicinal Cannabis
Members of the Spanish Observatory of Medicinal Cannabis

2016-01-26 Medical marijuana

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