Cannabinoids and terpenes

Before we start talking about the different consumption methods available, it is worth mentioning that they all have something in common: the cannabis is heated. During this process, high temperatures cause the cannabinoids to decarboxylate, turning them into pharmacologically active compounds.

Decarboxylation is a chemical reaction that removes a carboxyl group (-COOH) from a compound in the form of carbon dioxide (CO2). This process activates the plant’s cannabinoids, which are found in their acid form (like THCA and CBDA) and transforms them into the cannabinoids that we know (THC and CBD).

It is important to highlight that cannabis decarboxylation is necessary for cannabis to produce its psychoactive effects, because THC in its acid form (THCA) does not produce the psychoactivity traditionally associated with marijuana. Therefore, even when it’s being ingested, it is advisable to first heat the cannabis (cooking it in some way) to activate its components.

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From the fuel flavoured OG Kush to the citric Lemon Haze or the typically skunky Sour Diesel, there is a plethora of flavours from which marijuana lovers can choose their favourite weed.

The main components of the cannabis plant responsible for its characteristic aroma and flavour are terpenes. They are divided into monoterpenes (10 carbon atoms) and sesquiterpenes (15 carbon atoms). Depending on their proportion, variety, and combination, they can generate thousands of different organoleptic profiles. Terpenes, along with cannabinoids, develop in the plant’s resin glands (trichomes). The higher the number of trichomes, the more intense the aromatic combination.

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What is Delta-8-THC?

• Name: Delta 8 Tetrahydrocannabinol, Δ8-THC
• Formula: C21H30O2
• IUPAC name: (6aR, 10aR) -6,6,9-trimethyl-3-pentyl-6a, 7,10,10a-tetrahydrobenzo [c]chromen-1-ol
• Molecular mass: 314.5 g/mol
• Boiling point: 383.5 ± 42.0 ° C

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The cannabis that we consume today is much more potent than it was 40 years ago. If you follow the news about the industry you've most likely heard someone express some version of that sentiment. And it appears that the figures can confirm this: records show that, in the 80s, cannabis had THC levels of 2 to 5%, while today, we find many varieties that reach 20% THC on average, which backs up the claim that today's cannabis is 4-5 times more potent than it was in the 1980s.

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Many people believe we can only get CBD from cannabis, and the hemp industry has taken huge advantage of this misconception. Some consumers think they are limited to this type of CBD (cannabidiol) which can be prone to contamination, legality, and consistency issues.

Hemp-derived CBD is very cheap and useful in the right context. However, like with all things in life, it's always nice to have different options.

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What is myrcene?

• Name: Myrcene, β-myrcene
• Chemical formula: C10H16
• IUPAC name: 7-Methyl-3-methyleneocta-1,6-diene
• Density: 794kg/m3
• Molar mass: 136,23g/mol
• Boiling point: 167ºC
• Appearance: Yellowish non-water soluble oily liquid

Myrcene is one of the main terpenes found in the cannabis plant, often the most common, and certainly one of the most researched. As we already saw in our article on cannabis terpenes, these non-psychoactive organic compounds give the plants their characteristic aroma and flavour, and have different properties with a huge therapeutic potential. Terpenes - sometimes known as isoprenoids - are molecules derived from isoprene, so they are considered as hydrocarbons. They can contain 10 carbon atoms (like the compound we are discussing here - and then we’ll be talking about monoterpenes), or 15 carbon atoms, which are the so-called sesquiterpenes.

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Δ9-Tetrahydrocannabiphorol: the new holy grail of cannabis?

Towards the end of 2019, a team of Italian scientists investigating the properties of cannabis came upon something totally unexpected: two new and important cannabinoids.

These cannabinoids turned out to be very similar to regular THC (Tetrahydrocannabinol) and CBD (Cannabidiol), but with a greater number of carbon atoms in their alkyl side chain, which means their properties and even their potency are modified.

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The many different varieties of cannabis contain hundreds of compounds (the exact number is hard to calculate), each with its own characteristics and properties. You'll most likely have heard of cannabinoids, terpenes and flavonoids as components of the plant, with the first two occupying much of the general interest. However, it is estimated that flavonoids represent 10% of the total substances produced by the plant, and 2.5% of the dry weight in leaves and flowers. But what are flavonoids? What is their purpose, and how do they act? In this article we will answer these questions.

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What is CBG?

• Name: Cannabigerol
• Formula: C21H32O2
• IUPAC name: 2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-pentylbenzene-1,3-diol
• Molecular mass: 316,48 g/mol
• Boiling point: Not available
• Apearance: White powder/crystals

Discovered by Gaoni and Mechoulam in 1964, CBG or cannabigerol is one of the cannabinoids exclusively produced by the cannabis plant, which is stored in the trichome heads with the rest of cannabinoids and terpenes. While the CBG content in most plants is often low or very low - in most cases lower than 1% - this particular compound is crucial for cannabinoid synthesis, as we have known for the past 4 decades ( (Shoyama, Yagi and Nishioka, Phytochemistry Journal, October 1975). As a general rule, hemp contains higher amounts of CBG than commercial, narcotic cannabis strains.

CBG is a non-psychoactive phytocannabinoid, which means it is produced by plants and does not "get you high". It is believed that it has multiple medicinal properties which can be used to treat different conditions, and is also precursor - its acid form, to be exact - to the main cannabinoids (THCA, CBDA, CBCA) secreted in the trichome heads, which in turn explains the low percentage of CBG found in mature plants when compared to their THC or CBD content.

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What is the entourage effect?

The so-called entourage effect (sometimes referred to as the ensemble effect) is a term used for the first time in a study on the interaction between various compounds present in cannabis, published in the July 1998 issue of the European Journal of Pharmacology. This text (An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity) was written by researchers and scientists including Professor Raphael Mechoulam and Shimon Ben-Shabat among others, and demonstrates the increase in activity of a given cannabinoid thanks to the presence of another compound, in this case the esters of a fatty acid. However, as research has progressed over the years, this term has been coined to refer to the interaction, or synergy between the various cannabinoids, terpenes and flavonoids present in the plant that define the effects of cannabis.

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What is Pinene?

• Name: Pinene, alpha-pinene, beta-pinene
• Formula: C10 H16
• IUPAC name: (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene
• Molar mass: 136.24 g/mol
• Boiling point: 155-156ºC
• Appearance at room temperature: Liquid, almost insoluble in water

Pinene is a bicyclic monoterpene widely found in the resin of many plant species, from conifers (pine trees, spruces) to non-conifer plants like wormwood, rosemary, sage, heterotheca or cannabis. Two isomers are found in Nature, called alpha-pinene (?-pinene) and beta-pinene (?-pinene), which can be found in substances like pine resin, turpentine or camphene and are also used by many insects to communicate. Pinene is also a common terpene in a large number of cannabis strains, being highly appreciated by many users for its beneficial properties.

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What is Cannabicyclol?

• Name: Cannabicyclol
• Formula: C21 H30 O2
• IUPAC Name: (1aR- (1a alpha, 3a alpha, 8b alpha, 8c alpha)) - 1a, 2, 3, 3a, 8b, 8c-hexahydro-1,1,3a-trimethyl-6-pentyl-1H- 4-oxabenzo (f) cyclobut (cd) inden-8-ol
• Molar mass: 314.469 g/mol

Cannabicyclol, also called CBL, is one of the least known and studied cannabinoids in the cannabis plant. Although it is commonly found in many varieties, in particular those with a higher content of CBC (Cannabichromene), the amount of CBL produced in trichomes is always very low, so it doesn't usually receive the attention given to other, more plentiful compounds of the plant with a much more noticeable presence, such as THC, CBD or CBN.

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What is THC?

• Name: Tetrahydrocannabinol or delta-9-tetrahydrocannabinol
• Formula: C21H30O2
• IUPAC Name: Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzene [b, d] pyran-1-ol
• Molecular weight: 314.45 g / mol
• Boiling point: 157ºC
• Presence at room temperature: crystalline solid at low temperature, viscous when heated
• Not soluble in water, highly soluble in lipids, alcohols and hydrocarbons such as butane

Without a doubt, THC (often called delta-9-THC) is the most widely known cannabinoid of the cannabis plant. Although it is almost completely absent in some - usually hemp - varieties, that barely reach 1%, the drug varieties of cannabis show a high content (up to 30%) of what is the main psychotropic compound produced in the trichomes of the marijuana. Indeed, THC is the most important psychoactive component of cannabis, responsible for the "high" sensation commonly associated with the consumption of this plant and which has made it illegal in most countries of the world.

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What is Limonene?

• Name: Limonene, d-limonene
• Formula: C10H16
• IUPAC Name: 1-methyl-4-(1-methylethenyl)-cyclohexene
• Density: 841.1 kg/m3
• Molar mass: 136.23 g/mol
• Boiling point: 176ºC/348.8ºF
• Presence at room temperature: Colourless liquid, very low solubility in water

Limonene is one of the most widely used monoterpenes - aromatic molecules produced by a large number of plants - in the industry, either to make food or as constituents of perfumes, medicines or detergents, also to manufacture biodegradable solvents or to replace toxic solvents. It is a terpene commonly related to cannabis, since many of the existing cannabis strains contain limonene to a greater or lesser degree. Citrus fruits also contain high amounts of limonene, especially in the peel, as well as other plants like mint, rosemary or juniper.

It is usually classed among limonoids along with other terpenes like pinene or eucalyptol, which are often found together in the same fruits. The D-isomer (also called R or alpha) has intense citric aroma, reminiscent of oranges or lemons, while the L-isomer (also called S or beta) is closer to pine trees. Limonene is used in the industry to mask other odours or flavours, and - along with camphene - can be obtained by catalysing another well known aromatic compound, pinene. The most widely used methods to extract limonene - and other terpenes - from fruits are steam distillation or centrifugal force.

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What is CBN?

• Name: Cannabinol
• Formula: C21H26O2
• IUPAC name: 6,6,9-trimethyl-3-pentylbenzo [c] chromen-1-ol
• Molecular mass: 310.4319 g / mol
• Melting point: 77 ° C
• Boiling point: 185 ° C
• Presence at room temperature: Solid, crystalline and colorless

CBN or cannabinol is one of the most important compounds found in cannabis, along with THC or CBD. Although the proportion of CBN is usually quite low (no more than 1%), especially when compared to the main psychoactive component of the plant, THC (which can reach almost 30%), this cannabinoid has a number of therapeutic properties of great value for a multitude of medicinal users, which has led to studies and tests on the possible applications of CBN becoming increasingly numerous.

CBN is a cannabinoid produced exclusively by the cannabis plant, and it can not be found in any other plant species. Its psychoactivity is low, which for many medicinal users represents a great advantage, and it is believed to be the cause of the sedative and narcotic effect of some varieties of cannabis, in addition to being a partial agonist of the CB1 and CB2 receptors, being somewhat more linked with the CB2 receptor (inhibits adenylate cyclase). It is a molecule that is readily dissolved in fats or the various solvents used to make cannabis resin extractions, being hydrophobic (water repellent) and lipophilic (having affinity for lipids).

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What is CBC?

• Name: Cannabichromene
• Formula: C21H30O2
• IUPAC name: 2-methyl-2- (4-methylpent-3-enyl) -7-pentylchromen-5-ol
• Molecular weight: 314.469 g/mol
• Boiling point: 220 ° C

Although the amount of cannabichromene that's normally found in analysis of modern cannabis flower or resin samples is relatively small, indeed significantly lower than that of THC, or even CBD (in many cases), CBC is still classified as a major phytocannabinoid produced by the cannabis plant, sharing as it does structural similarities with some of the most important cannabinoids (THC, CBD, CBN or THCV) and in fact sharing a formula with the much better known THC and CBD.

Cannabichromene was discovered in 1966 by Gaoni and Mechoulam on one hand and almost simultaneously by Claussen on the other, although since then little research has been carried out on this cannabinoid, with THC and CBD being the protagonists of the majority of subsequent studies. However, as we will see below, today there is a growing body of evidence demonstrating the tremendous therapeutic potential of this cannabinoid, especially in combination with other compounds in what is often referred to as an ?ensemble? effect.

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