Cannabinoids and terpenes -

Pinene: A terpene that can improve your memory

What is Pinene? Name: Pinene, alpha-pinene, beta-pinene Formula: C10 H16 IUPAC name: (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene Molar mass: 136.24 g/mol Boiling point: 155-156ºC Appearance at room temperature: Liquid, almost insoluble in water Pinene is a bicyclic monoterpene widely found in the resin of many plant species, from conifers (pine trees, spruces) to non-conifer plants like wormwood, rosemary, sage, heterotheca or cannabis. Two isomers are found in Nature, called alpha-pinene (?-pinene) and beta-pinene (?-pinene), which can be found in substances like pine resin, turpentine or camphene and are also used by many insects to communicate. Pinene is also a common terpene in a large number of cannabis strains, being highly appreciated by many users for its beneficial properties.

Cannabicyclol (CBL) - A cannabinoid in need of investigation

What is Cannabicyclol? Name: Cannabicyclol Formula: C21 H30 O2 IUPAC Name: (1aR- (1a alpha, 3a alpha, 8b alpha, 8c alpha)) - 1a, 2, 3, 3a, 8b, 8c-hexahydro-1,1,3a-trimethyl-6-pentyl-1H- 4-oxabenzo (f) cyclobut (cd) inden-8-ol Molar mass: 314.469 g/mol Cannabicyclol, also called CBL, is one of the least known and studied cannabinoids in the cannabis plant. Although it is commonly found in many varieties, in particular those with a higher content of CBC (Cannabichromene), the amount of CBL produced in trichomes is always very low, so it doesn't usually receive the attention given to other, more plentiful compounds of the plant with a much more noticeable presence, such as THC, CBD or CBN.

Tetrahydrocannabinol (THC): The principal cannabinoid in cannabis

What is THC? Name: Tetrahydrocannabinol or delta-9-tetrahydrocannabinol Formula: C21H30O2 IUPAC Name: Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzene [b, d] pyran-1-ol Molecular weight: 314.45 g / mol Boiling point: 157ºC Presence at room temperature: crystalline solid at low temperature, viscous when heated Not soluble in water, highly soluble in lipids, alcohols and hydrocarbons such as butane Without a doubt, THC (often called delta-9-THC) is the most widely known cannabinoid of the cannabis plant. Although it is almost completely absent in some - usually hemp - varieties, that barely reach 1%, the drug varieties of cannabis show a high content (up to 30%) of what is the main psychotropic compound produced in the trichomes of the marijuana. Indeed, THC is the most important psychoactive component of cannabis, responsible for the "high" sensation commonly associated with the consumption of this plant and which has made it illegal in most countries of the world.

Limonene: An essential terpene in Nature

What is Limonene? Name: Limonene, d-limonene Formula: C10H16 IUPAC Name: 1-methyl-4-(1-methylethenyl)-cyclohexene Density: 841.1 kg/m3 Molar mass: 136.23 g/mol Boiling point: 176ºC/348.8ºF Presence at room temperature: Colourless liquid, very low solubility in water Limonene is one of the most widely used monoterpenes - aromatic molecules produced by a large number of plants - in the industry, either to make food or as constituents of perfumes, medicines, or detergents, also to manufacture biodegradable solvents or to replace toxic solvents. It is a terpene commonly related to cannabis since many of the existing cannabis strains contain limonene to a greater or lesser degree. Citrus fruits also contain high amounts of limonene, especially in the peel, as well as other plants like mint, rosemary, or juniper. It is usually classed among limonoids along with other terpenes like pinene or eucalyptol, which are often found together in the same fruits. The D-isomer (also called R or alpha) has an intense citric aroma, reminiscent of oranges or lemons, while the L-isomer (also called S or beta) is closer to pine trees. Limonene is used in the industry to mask other odors or flavors, and - along with camphene - can be obtained by catalyzing another well-known aromatic compound, pinene. The most widely used methods to extract limonene - and other terpenes - from fruits are steam distillation or centrifugal force.

Cannabinol (CBN): The Cannabinoid Against Insomnia

What is CBN? Name: Cannabinol Formula: C21H26O2 IUPAC name: 6,6,9-trimethyl-3-pentylbenzo [c] chromen-1-ol Molecular mass: 310.4319 g / mol Melting point: 77 ° C Boiling point: 185 ° C Presence at room temperature: Solid, crystalline and colorless CBN or cannabinol is one of the most important compounds found in cannabis, along with THC or CBD. Although the proportion of CBN is usually quite low (no more than 1%), especially when compared to the main psychoactive component of the plant, THC (which can reach almost 30%), this cannabinoid has a number of therapeutic properties of great value for a multitude of medicinal users, which has led to studies and tests on the possible applications of CBN becoming increasingly numerous. CBN is a cannabinoid produced exclusively by the cannabis plant, and it can not be found in any other plant species. Its psychoactivity is low, which for many medicinal users represents a great advantage, and it is believed to be the cause of the sedative and narcotic effect of some varieties of cannabis, in addition to being a partial agonist of the CB1 and CB2 receptors, being somewhat more linked with the CB2 receptor (inhibits adenylate cyclase). It is a molecule that is readily dissolved in fats or the various solvents used to make cannabis resin extractions, being hydrophobic (water repellent) and lipophilic (having affinity for lipids).

Cannabichromene (CBC): a cannabinoid with therapeutic potential

While cannabichromene (CBC) may not be the most popular cannabinoid, the lastest scientifical research shows a very promising future for this cannabis compound, which is focusing the attention of both the medical community and many marijuana breeders and seed companies.

Hashishene, the new terpene of cannabis

Hashish and terpenes As we already know, terpenes are responsible for the taste and scent of many of the vegetables that produce them. They are a broad class of organic hydrocarbons derived from isoprene (CH2=C(CH3)CH=CH2) which compose the bulk of resins and essential oils of plants, thus providing unique flavours to each individual as a result of terpene combination. They are also called terpenoids when they have undergone an oxidating or molecular re-combination process. As we also know, most cannabis terpenes have properties of great medicinal value. As the flowering stage progresses, more and more terpenes are secreted inside the trichome heads, so that the terpene profile of the plant changes as it ripens. The same thing happens when drying and curing buds, the process of oxidation and partial decarboxylation to which buds are exposed makes their terpene range to change over time. Some terpenes will degrade faster than others, so the terpene range of the weed - we must remember that we know of more than 100 terpenes in cannabis - will vary unless it is vacuum-sealed and properly stored. This fact explains why the smell and taste of one sample can evolve throughout the drying and curing process.

Cannabinoids and their medicinal properties

The cannabis plant and phytocannabinoids THC, CBD, CBN, CBC, CBG and approxiamately 80 more molecules make up the phytocannabinoids family, which are found in varying amounts, depending on environmental conditions, andt the marijuana plant. Some cannabinoids are responsible for the main effects of cannabis and others have important medicinal properties, that the scientific community continues to discover every day. Some cannabinoids are mainly antidepressants, anti-inflammatory, anti-anxiety, anti emetic, while others may even help protect the nervous system. Actually, we are just beginning to discover the potential of cannabinoids and all their possible applications, mainly in the context of some cancers, as well as other degenerative diseases. We can classify the cannabinoids into four major groups: natural cannabinoids from plants (phytocannabinoids), natural endogenous cannabinoids (endocannabinoids produced by the human body and securing biological functions), cannabinoids synthesis (potentially dangerous, as there is very little information on its effects), and mimetic or cannabimimetic cannabinoids (naturally occurring molecule or synthetic, replicating the action of cannabinoids on CB1 and / or CB2 receptors). In this article, we will only discuss the naturally occurring cannabinoids in the marijuana plant, the phytocannabinoids. Most of the cannabinoids are present in very small amounts (less than 0.01% of total cannabinoids) are not considered psychoactive, and the effect is not significant. Indeed, many are simply homologues or analogues (similar structure or function) of some of the major known cannabinoids. However, medical research regularly reveals new and surprising discoveries about these cannabinoids present in trace form. Unfortunately, this research and its findings are significantly hampered by the leglisation in many countries. Different mixtures of cannabinoids and other related molecules (mainly aromatic compounds such as myrcene), largely explain the variations of effects we found between one variety of cannabis and another. The strength of the effect depends mainly on the level of THC, THC / CBD ratio and form of consumption, but this effect can also be modulated in several different ways.

Marijuana terpenes and their effects

The genetic diversity of marijuana