Limonene: An essential terpene in Nature

What is Limonene?

  • Name: Limonene, d-limonene
  • Formula: C10H16
  • IUPAC Name: 1-methyl-4-(1-methylethenyl)-cyclohexene
  • Density: 841.1 kg/m3
  • Molar mass: 136.23 g/mol
  • Boiling point: 176ºC/348.8ºF
  • Presence at room temperature: Colourless liquid, very low solubility in water

Limonene is one of the most widely used monoterpenes - aromatic molecules produced by a large number of plants - in the industry, either to make food or as constituents of perfumes, medicines or detergents, also to manufacture biodegradable solvents or to replace toxic solvents. It is a terpene commonly related to cannabis, since many of the existing cannabis strains contain limonene to a greater or lesser degree. Citrus fruits also contain high amounts of limonene, especially in the peel, as well as other plants like mint, rosemary or juniper.

It is usually classed among limonoids along with other terpenes like pinene or eucalyptol, which are often found together in the same fruits. The D-isomer (also called R or alpha) has intense citric aroma, reminiscent of oranges or lemons, while the L-isomer (also called S or beta) is closer to pine trees. Limonene is used in the industry to mask other odours or flavours, and - along with camphene - can be obtained by catalysing another well known aromatic compound, pinene. The most widely used methods to extract limonene - and other terpenes - from fruits are steam distillation or centrifugal force.

Limonene molecule
Limonene molecule

Synthesis of limonene

As happens with other monoterpenes (terpenes with 10 carbons) present in cannabis, limonene comes from geranyl pyrophosphate. However, and as we already know, not all cannabis plants produce the same amount of each cannabinoid or terpene, so every plant has its own, unique profile. Limonene is, in turn, precussor of a terpenoid called carvone (found in juniper and peppermint, among others) and also of perillyl alcohol and P-cymene, which is obtained by catalytic dehydrogenation of limonene and shares a multitude of uses with it in the industry. Limonene oxidises when it comes in contact with air, producing carveol, limonene oxide and the aforementioned carvone, as well as other potent allergens.

It is believed that plants produce limonene as natural insecticide, which repels insects thanks to its intense smell. Limonene is the second most found terpene in Nature (after pinene, which is the first) which suggests that it is a compound with enormous potential. Besides other plants, it is mostly found in lemons, limes, oranges, mandarins or grapefruits.

Synthesis of limonene from geranyl pyrophosphate
Synthesis of limonene from geranyl pyrophosphate

Smell and taste of limonene

While this point may seem obvious, the truth is that the smell and taste of limonene vary depending on each isomer. The scent of D-limonene is closer to oranges, with sweet and lemony notes. On the other hand, the L-isomer is reminiscent of pine trees with citric and solvent notes.

Properties and effects of limonene

The medicinal properties of this cyclic carbohydrate are numerous and well known. Besides its applications on the medical field, it is also being increasingly used in the industry to replace toxic substances. Among its many uses, the following are highlighted for their multiple applications and the numerous studies proving their efficacy:

  • Industrial biodegradable solvent for resins, dyes, greases, oils or pigments
  • Recyclable solvent for extractions (it has been used to replace hexane when extracting oil from rice bran)
  • Cleaning of sewers and drains
  • Manufacturing of paints and glues
  • Flavouring agent for foods
  • Flavouring excipient for medicines (it masks the bitter taste of alkaloids)
  • Aromatic component in perfumes and cosmetics
  • Insect repellent (especially the D-isomer)
  • Synthesis of other compounds

Many cannabis plants contain limonene
Many cannabis plants contain limonene

Furthermore, limonene also has a number of medicinal properties of great interest and potential, such as:

  • Anti-cancer effect (this molecule increases the levels of hepatic enzymes involved in detoxification of carcinogenics, promoting the activity of the GST system. It also metabolizes carcinogenic substances into less toxic compounds)
  • Tumour reduction in mammals (anti-inflammatory properties)
  • Triggering of entourage effect with cannabioids like THC-A, CBD-A, CBC-A, CBC, CBG or terpenes like linalool or caryophyllene by reducing permeability of skin, digestive tract and mucous membranes
  • Anxiolytic/anti-depressive effect (widely used in aromatherapy to treat stress and improve mood)
  • Antiseptic properties
  • Anti-bacterial and anti-fungal agent
  • Tissue regeneration (damaged skin, acne, athlete's food)
  • Ulcer and acid reflux treatments
  • Treatment of gallstones and kidney stones

Toxicity of limonene is low; adverse reactions after using it are uncommon, although cases of irritant reactions on the skin and respiratory system after prolonged industrial exposure may  appear. Still, it is considered a safe compound for humans.

O'Haze Red by Reggae Seeds
O'Haze Red by Reggae Seeds contains high amounts of limonene

Cannabis strains with high limonene content

The number of genetics with considerable amounts of limonene is huge, especially if we focus on Sativa varieties. The scent and taste of this terpene is highly appreciated by many cannabis users, since it creates a wide range of fruity and citric hints. The following strains usually reach high limonene content:

Without a doubt, limonene is one of the most important terpenes in Nature, with endless applications in both the industrial and medical fields. It can be easily extracted and has a large number of properties, which makes it a widely used compound in different industrial sectors. Furthermore, its amazing therapeutic and organoleptic properties give this compound a promising future with regard to cannabis breeding.

Happy growing!

Studies and publications on limonene consulted for the writing of this article:


The articles published by Alchimiaweb, S.L. are reserved for adult clients only. In France, the age of majority is set at 18 years old. Consult your country's legislation and obey it. Alchimiaweb, SL is a Spanish company governed by Spanish law and can not, in any case, be held responsible for any misuse or non-compliance with the laws and regulations specific to each country, in relation to the articles published on its Blog. We remind you that the cultivation of cannabis seeds on French territory is strongly prohibited by law. We do not encourage our customers to break the law in any way and are not responsible for their use.

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